NCCN Harmonized Guidelines™

NCCN Guidelines® & Clinical Resources

NCCN Guidelines are used by clinicians around the world as a standard resource for clinical decision-making. The NCCN Harmonized Guidelines are targeted regional resources created as part of a collaborative effort to combat the skyrocketing cancer rates and unique circumstances of cancer care. They represent both the optimal care that resource-constrained areas aspire to provide and pragmatic approaches that could be used to improve the availability of effective treatment options.

Using the Harmonized Guidelines

Recommendations within the NCCN Harmonized Guidelines are represented as follows:

  • Black Text: Generally available standard of care
  • Gray Text: Highly advanced/optimal care that may be costly, technically challenging, and/or have a lesser impact on oncologic outcome
  • Blue Text: Regional options that may be considered when availability precludes general standard of care
  • Gray Strikethrough Text: Indicates care options that are not feasible or available at this time

View available Harmonized Guidelines below or download the Virtual Library of NCCN Guidelines® App for your mobile device.

NCCN Harmonized Guidelines for Sub-Saharan Africa

As part of a joint project with the African Cancer Coalition (ACC), American Cancer Society (ACS), the Clinton Health Access Initiative (CHAI), and IBM, NCCN and members of ACC adapted the NCCN Guidelines® and NCCN Framework for Resource Stratification of NCCN Guidelines (NCCN Framework) to create the NCCN Harmonized Guidelines for Sub-Saharan Africa.

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Expanding efforts to address cancer in Sub-Saharan Africa

In 2019, ACS, NCCN and CHAI announced a new alliance to help improve access to high-quality cancer care and treatment in Sub-Saharan Africa called Allied Against Cancer. The Alliance will support a network of African oncology experts and technical assistance partners to help improve the quality of cancer care, including collaborating closely with the African Cancer Coalition to establish priorities and execute these initiatives locally.

One of the goals of this collaboration is to implement the NCCN Harmonized Guidelines and provide training for an expanded group of cancer care providers to use these guidelines to improve the availability of effective therapies for people with cancer in Sub-Saharan Africa.

The involvement of experts from Sub-Saharan Africa has been key to the success of this effort. The ACC, which consists of more than 100 oncologists and other multidisciplinary cancer care physicians from over 30 hospitals, universities, and Ministries of Health in 13 Sub-Saharan African countries, has participated in the harmonization process. This initiative spans national borders in Africa and spans continents in a collaborative effort. The knowledge that the ACC representatives bring to the table is extensive and invaluable. They know the challenges and many solutions to delivering cancer care in resource-constrained environments. Any success in the effort to improve oncology care in Africa is largely thanks to the dedication and participation of NCCN’s African colleagues.

NCCN Harmonized Guidelines for the Caribbean

The Caribbean archipelago that extends from the Bahamas in the north to Trinidad and Tobago in the south ranks among the highest regions in the world for cancer prevalence. Cancer is the second leading cause of death in the Caribbean, and the rate of breast cancer deaths is currently twice that of the United States. As part of a joint project with the Caribbean Association for Oncology & Hematology (CAOH), NCCN and members of CAOH are adapting the NCCN Guidelines to create the NCCN Harmonized Guidelines for the Caribbean. NCCN Guidelines Panel Members participated in a working session with the members of CAOH to adapt the NCCN Guidelines and NCCN Framework to create the NCCN Harmonized Guidelines for the Caribbean in order to better reflect the diverse needs and resources throughout the Caribbean.

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Additional NCCN Harmonized Guidelines™ for the Caribbean coming soon.

For more information about NCCN collaborations to create the NCCN Harmonized Guidelines™, visit NCCN.org/news.